Geoffrey Liu Laboratory
About the Liu Lab
The Liu laboratory is a cancer pharmacogenomic epidemiologic, translational and clinical laboratory
The Geoffrey Liu laboratory is a multidisciplinary, collaborative translational laboratory that seeks to improve outcomes in cancer. The laboratory has four main programs and a multi-level training program:
AMP-PEL program:
stands for Applied Molecular, Pharmacoepidemiologic, Pharmacogenomic, and Epidemiologic Laboratory, and focuses on identifying and validating cancer biomarkers:
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Project 1: using mouse (REAL-PDX: Resistance modeling in EGFR and ALK Lung cancer Patient-Derived Xenografts for personalized post-progression therapy) models
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Project 2: organoid cell culture (NERO: Non-small cell lung cancer with EGFR and Rearranged molecular alterations for Organoid models) models
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Project 3: human population studies (COS-ILCCO: Clinical Outcomes Studies of the International Lung Cancer Consortium Studies of Clinical Outcomes) and understanding
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Project 4: developing improved patient phenotyping of symptoms and toxicities: (2BLAST: Biostatistical and Bioinformatic Longitudinal Assessment of Symptoms and Toxicities)
CALIBRE program:
stands for Clinical And LIquid biopsy, Breathomics, and Radiomics for Early detection of Cancer
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Project 1: Clinical and Implementation Studies in Lung Cancer Screening
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Project 2: Radiomics in Lung Cancer Screening
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Project 3: Liquid Biopsies in Lung Cancer in Early Detection
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Project 4: Breathomics in Lung Cancer Early Detection
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Project 5: CALIBRE Integrative Analysis for Lung Cancer Screening
ON-PROST program:
stands for ONtario Patient Reported Outcomes of Symptoms and Toxicity
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Project 1: CARMA BROS is the CAnadian Rare Molecular Alterations Basket Real-world Observational Study
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Project 2: CLINTA stands for CLInic-based New Technology Applications
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Project 3: CHUQoLS (pronounced Chuckles) stands for Cancer Health Utilities and Quality of Life Studies
HANG-OUT program:
stands for Head And Neck cancer network for Genetics, Observational oUtcomes, and Toxicities: A combined AMP-PEL and ON-PROST initiative
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Project 1: GENE-SMOKE:
Genetics of Smoking Outcomes and Knowledge Effects
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Project 2: GENE-LAST:
Genetics of Long and Short-term Toxicities
COMBIEL Training Program: Cancer Outcomes, Medicine, Biostatistics, Informatics, EpidemiologyLaboratory Training Program (see www.uhncombiel.com for details)